Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15293
Abstract: The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A domain of Munc13 inhibits the priming function by homodimerization,… read more here.
Keywords: vesicle docking; docking priming; c2a domain; munc13 ... See more keywords
The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1123561
Abstract: There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release.… read more here.
Keywords: priming fusion; role; neurotransmitter release; docking priming ... See more keywords