Strain-Specific Propagation by an Amyloid-Beta Dodecamer
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1962
Abstract: Soluble oligomers of the amyloid-β (Aβ) peptide have emerged as the primary neurotoxic agents in Alzheimer disease (AD). Increasing evidence implicates aggregates of Aβ to propagate towards fibrils in a strain-specific manner. Morphological differences observed… read more here.
Keywords: propagation; seed; dodecamer; specific propagation ... See more keywords
On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer.
Sign Up to like & getrecommendations! Published in 2024 at "Dalton transactions"
DOI: 10.1039/d3dt04302a
Abstract: The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticancer compounds is arsenoplatin-1 (AP-1) that contains an As(OH)2 fragment linked to a Pt(II)… read more here.
Keywords: binding dna; action arsenoplatins; mechanism action; dodecamer ... See more keywords