Practice variation in the re-initiation of dofetilide: An observational study.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.01.157
Abstract: BACKGROUND Dofetilide is a class III antiarrhythmic drug that has been reported to be safe and efficacious in the treatment of atrial dysrhythmias with a known initial risk of QT prolongation and torsades de pointes… read more here.
Keywords: variation; initiation; initiation dofetilide; protocol ... See more keywords
COMBINATION THERAPY WITH DOFETILIDE AND MEXILETINE FOR ATRIAL FIBRILLATION: INCREASED EFFICACY AND DECREASED QT INTERVAL PROLONGATION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)31108-6
Abstract: Dofetilide, a class III antiarrhythmic is indicated for conversion of atrial fibrillation (AF) to sinus rhythm and maintenance of sinus rhythm. Dofetilide works by blocking the repolarizing potassium currents and hence prolongs QT interval. QT… read more here.
Keywords: atrial fibrillation; combination therapy; dofetilide; interval prolongation ... See more keywords
Longitudinal QTc stability and impact of baseline cardiac rhythm on discharge dose in dofetilide‐treated patients
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DOI: 10.1111/jce.15483
Abstract: Dofetilide suppresses atrial fibrillation (AF) in a dose‐dependent fashion. The protective effect of AF against QTc prolongation induced torsades de pointe and transient post‐cardioversion QTc prolongation may result in dofetilide under‐dosing during initiation. Thus, the… read more here.
Keywords: stability; impact baseline; discharge dose; dofetilide ... See more keywords
Dofetilide-induced torsade de pointes in high-grade atrioventricular node dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Postgraduate Medical Journal"
DOI: 10.1136/postgradmedj-2017-134933
Abstract: A 64-year-old woman received 29 mm Mosaic mitral bioprosthesis in 2010 after failure of valve repair attempt. Subsequently she underwent percutaneous insertion of tricuspid valve Biocor Epic 31 prosthesis, which was complicated by complete atrioventricular (AV)… read more here.
Keywords: induced torsade; dofetilide induced; pointes high; dysfunction ... See more keywords
Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study
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DOI: 10.1371/journal.pone.0201059
Abstract: Background Dofetilide is an effective antiarrhythmic medication for rhythm control in atrial fibrillation, but carries a significant risk of pro-arrhythmia and requires meticulous dosing and monitoring. The cornerstone of this monitoring, measurement of the QT/QTc… read more here.
Keywords: dofetilide plasma; dofetilide; plasma concentration; deep learning ... See more keywords