Old dog, new tricks: Influenza a virus NS1 and in vitro fibrillogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.07.005
Abstract: The influenza NS1 protein is involved in suppression of the host immune response. Recently, there is growing evidence that prion-like protein aggregation plays an important role in cellular signaling and immune responses. In this work,… read more here.
Keywords: dog new; new tricks; tricks influenza; form ... See more keywords
Teaching an old dog new tricks: repurposing β-lactams.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.06.003
Abstract: Recently, Martelli and colleagues reported on the structural and functional characterization of new antimycobacterials based on N-thio-β-lactams. Surprisingly, the inhibitory mechanism follows a path unexpected for β-lactams, providing an alternative route to defeat drug-resistant strains… read more here.
Keywords: repurposing lactams; dog new; new tricks; tricks repurposing ... See more keywords
OLD DOG, NEW TRICK: NOVEL CT-DERIVED PARAMETER IS ASSOCIATED WITH LOW CARDIAC INDEX IN ACUTE PULMONARY EMBOLISM
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)32900-4
Abstract: Acute pulmonary embolism (PE) has variable outcomes. Current risk stratification models lack the positive predictive value to identify highest risk patients. We hypothesize that Hounsfield unit (HU) gradient is associated with transit time of IV… read more here.
Keywords: new trick; pulmonary embolism; dog new; acute pulmonary ... See more keywords
Gamma‐Glutamyl Transferase (γ‐GT) – an old dog with new tricks?
Sign Up to like & getrecommendations! Published in 2021 at "Liver International"
DOI: 10.1111/liv.15099
Abstract: Gamma‐Glutamyl Transferase (γGT) is a key transferase involved in the transpeptidation of functional gamma‐glutamyl groups to various receptor moieties. It performs important roles in antioxidant defence mechanisms, particularly glutathione recycling, xenobiotic metabolism, but analogously may… read more here.
Keywords: transferase old; old dog; glutamyl transferase; dog new ... See more keywords
Interstitial Adipocytes in the Beagle Dog and New Zealand White Rabbit Choroid Plexus
Sign Up to like & getrecommendations! Published in 2019 at "Toxicologic Pathology"
DOI: 10.1177/0192623319839916
Abstract: The choroid plexus (CP) produces cerebrospinal fluid and has epithelial, interstitial, and vascular compartments. The CP is a potential site of toxicity, and recognizing the normal microanatomy in different animal models is important for the… read more here.
Keywords: new zealand; choroid plexus; dog new; beagle dog ... See more keywords