Biophysical and modeling-based approach for the identification of inhibitors against DOHH from Leishmania donovani.
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DOI: 10.1093/bfgp/elac014
Abstract: The amino acid hypusine (Nε-4-amino-2-hydroxybutyl(lysine)) occurs only in isoforms of eukaryotic translation factor 5A (eIF5A) and has a role in initiating protein translation. Hypusinated eIF5A promotes translation and modulates mitochondrial function and oxygen consumption rates.… read more here.
Keywords: based approach; modeling based; biophysical modeling; leishmania donovani ... See more keywords