The cost‐effectiveness and budgetary impact of a dolutegravir‐based regimen as first‐line treatment of HIV infection in India
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25085
Abstract: Dolutegravir (DTG)‐based antiretroviral therapy (ART) is recommended for first‐line HIV treatment in the US and Europe. Efavirenz (EFV)‐based regimens remain the standard of care (SOC) in India. We examined the clinical and economic impact of… read more here.
Keywords: hiv infection; dolutegravir; line; first line ... See more keywords
Contraception use and HIV outcomes among women initiating dolutegravir‐containing antiretroviral therapy in Kenya: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.26046
Abstract: The rollout of dolutegravir (DTG) in low‐ and middle‐income countries was disrupted by a potential association reported with periconceptional DTG exposure among women living with HIV (WLHIV) and infant neural tube defects. This prompted countries… read more here.
Keywords: dolutegravir; among women; use hiv; contraception use ... See more keywords
Systematic De-escalation of Successful Triple Antiretroviral Therapy to Dual Therapy with Dolutegravir plus Emtricitabine or Lamivudine in Swiss HIV-positive Persons
Sign Up to like & getrecommendations! Published in 2018 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2018.11.005
Abstract: Background Studies increasingly suggest that the efficacy of certain dual antiretroviral therapy (ART) combinations is equal to triple ART. Increasing concerns among HIV-positive patients and physicians in Switzerland include ART cost and long-term ART safety… read more here.
Keywords: dolutegravir; art; therapy; escalation ... See more keywords
Comparative efficacy, tolerability and safety of dolutegravir and efavirenz 400mg among antiretroviral therapies for first-line HIV treatment: A systematic literature review and network meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "EClinicalMedicine"
DOI: 10.1016/j.eclinm.2020.100573
Abstract: Background To inform World Health Organization (WHO) global guidelines, we updated and expanded the evidence base to assess the comparative efficacy, tolerability, and safety of first-line antiretroviral therapy (ART) regimens. Methods We searched Embase, Medline… read more here.
Keywords: dolutegravir; line; first line; safety ... See more keywords
Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.113923
Abstract: Dolutegravir, raltegravir and darunavir are three antiretroviral drugs widely used in combined antiretroviral therapies. These three drugs are highly bound to plasma proteins. Compared to the total concentration, the concentration of unbound drug which is… read more here.
Keywords: raltegravir; dolutegravir; plasma; ultrafiltration ... See more keywords
An up-to-date evaluation of dolutegravir/abacavir/lamivudine for the treatment of HIV
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2029409
Abstract: ABSTRACT Introduction There are more than 30 agents available for the treatment of HIV with guidelines shifting toward integrase strand transfer inhibitors (INSTIs) as part of first line therapy. The fixed dose combination of dolutegravir… read more here.
Keywords: treatment hiv; hiv; treatment; dolutegravir ... See more keywords
Effect of dihydroartemisinin/piperaquine for malaria intermittent preventive treatment on dolutegravir exposure in pregnant women living with HIV
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DOI: 10.1093/jac/dkac081
Abstract: Abstract Background In sub-Saharan Africa, the burdens of malaria and HIV infections overlap. In settings with moderate-to-high malaria transmission intensity, pregnant women living with HIV (PLWH) require both ART and malaria intermittent preventive treatment (IPTp).… read more here.
Keywords: dolutegravir; pregnant women; dihydroartemisinin piperaquine; treatment ... See more keywords
Assessment of drug interaction potential between the HCV direct-acting antiviral agents elbasvir/grazoprevir and the HIV integrase inhibitors raltegravir and dolutegravir
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DOI: 10.1093/jac/dky465
Abstract: BACKGROUND Elbasvir/grazoprevir is a once-daily fixed-dose combination therapy for the treatment of chronic HCV infection, including HCV/HIV coinfection. OBJECTIVES To evaluate the pharmacokinetic interaction of elbasvir and grazoprevir with raltegravir or dolutegravir. METHODS Three open-label… read more here.
Keywords: dolutegravir; elbasvir grazoprevir; raltegravir dolutegravir;
Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance
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DOI: 10.1093/ofid/ofy329
Abstract: Abstract Dolutegravir (DTG), a second-generation integrase strand-transfer inhibitor (INSTI), is equivalent or superior to current non-nucleotide reverse transcriptase inhibitors (NNRTIs), protease inhibitors (PIs), and first-generation INSTI-based antiretroviral regimens (ARVs). It has the potential to make… read more here.
Keywords: drug resistance; r263k; dolutegravir; resistance ... See more keywords
Intolerance of dolutegravir-containing combination antiretroviral therapy: not just a pharmacokinetic drug interaction.
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DOI: 10.1097/qad.0000000000001394
Abstract: de Boer and colleagues [1] have recently reported the results of a postmarketing, ‘real-life,’ observational study, documenting a rate of discontinuation of dolutegravir (mainly for neuropsychological events) much higher than those reported previously in randomized… read more here.
Keywords: dolutegravir; containing combination; intolerance dolutegravir; dolutegravir containing ... See more keywords
Dolutegravir-induced extrapyramidal syndrome in a young woman.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS"
DOI: 10.1097/qad.0000000000002107
Abstract: A 30-year-old woman of sub-Saharan Africa origin attended our clinic in October 2016 for the follow-up of an HIV-1 infection. A treatment with combivir/ nevirapine was initiated in her country years ago. Laboratory testing indicated… read more here.
Keywords: tremor; dolutegravir; treatment; arm ... See more keywords