Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC-MS/MS.
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DOI: 10.1016/j.jpba.2021.113923
Abstract: Dolutegravir, raltegravir and darunavir are three antiretroviral drugs widely used in combined antiretroviral therapies. These three drugs are highly bound to plasma proteins. Compared to the total concentration, the concentration of unbound drug which is… read more here.
Keywords: raltegravir; dolutegravir; plasma; ultrafiltration ... See more keywords