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   Articles with "domain" as a keyword



Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding

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recommendations! Published in 2019 at "Febs Letters"

DOI: 10.1002/1873-3468.13667

Abstract: Several pathologies have been associated with the AAA+ ATPase p97, an enzyme essential to protein homeostasis. Heterozygous polymorphisms in p97 have been shown to cause neurological disease, while elevated proteotoxic stress in tumours has made… read more here.

Keywords: mechanism; atpase p97; p97; aaa atpase ... See more keywords
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Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3

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recommendations! Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13791

Abstract: Neurofibrillary tangles formed by abnormally aggregated tau protein are a histopathological feature of tauopathies. A tau aggregation inhibitor is a potential therapeutic agent for tauopathies. In this study, we prepared a monoclonal antibody for tau,… read more here.

Keywords: tau aggregation; crystal structure; domain; monoclonal antibody ... See more keywords

The T1‐tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel

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recommendations! Published in 2022 at "Febs Letters"

DOI: 10.1002/1873-3468.14279

Abstract: Cytoplasmic domains frequently promote functional assembly of multimeric ion channels. To investigate structural determinants of this process, we generated the ‘T1‐chimera’ construct of the NaChBac sodium channel by truncating its C‐terminal domain and splicing the… read more here.

Keywords: nachbac sodium; sodium channel; domain; channel ... See more keywords

TRAF trimers form immune signalling networks via RING domain dimerization

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14530

Abstract: For many inflammatory cytokines, the response elicited is dependent on the recruitment of the tumour necrosis factor receptor‐associated factor (TRAF) family of adaptor proteins. All TRAF proteins have a trimeric C‐terminal TRAF domain, while at… read more here.

Keywords: traf trimers; domain; ring domain; trimers form ... See more keywords

A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei.

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recommendations! Published in 2023 at "FEBS letters"

DOI: 10.1002/1873-3468.14632

Abstract: Copper radical oxidases (CROs) are redox enzymes able to oxidize alcohols or aldehydes, while only requiring a single copper atom as cofactor. Studied CROs are found in one of two subfamilies within the Auxiliary Activities… read more here.

Keywords: alcohol oxidase; burkholderia pseudomallei; domain;
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Combination therapy with androgen receptor N‐terminal domain antagonist EPI‐7170 and enzalutamide yields synergistic activity in AR‐V7‐positive prostate cancer

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recommendations! Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12770

Abstract: Resistance of castration‐resistant prostate cancer (CRPC) to enzalutamide and abiraterone involves the expression of constitutively active, truncated androgen receptor (AR) splice variants (AR‐Vs) that lack a C‐terminal ligand‐binding domain (LBD). Both full‐length AR and truncated… read more here.

Keywords: enzalutamide; prostate cancer; domain; epi 7170 ... See more keywords

PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain

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recommendations! Published in 2017 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12175

Abstract: Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric truncated form of the… read more here.

Keywords: hpah; regulatory domain; phenylalanine; phenylalanine hydroxylase ... See more keywords

Bovine natural antibody IgM inhibits the binding of human norovirus protruding domain to its HBGA receptors

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recommendations! Published in 2022 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13450

Abstract: Human norovirus (HuNoV) is the primary viral pathogen that causes acute gastroenteritis (AGE) in humans. The protruding (P) domain of HuNoV interacts with cell surface histo‐blood group antigens (HBGAs) to initiate infection. Owing to the… read more here.

Keywords: natural antibody; hbga receptors; protruding domain; domain ... See more keywords

Crystal structure of pectocin M1 reveals diverse conformations and interactions during its initial step via the ferredoxin uptake system

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recommendations! Published in 2024 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13874

Abstract: Pectocin M1 (PM1), the bacteriocin from phytopathogenic Pectobacterium carotovorum which causes soft rot disease, has a unique ferredoxin domain that allows it to use FusA of the plant ferredoxin uptake system. To probe the structure‐based… read more here.

Keywords: uptake system; pectocin; structure; ferredoxin ... See more keywords

Revealing the Atomic Defects of WS2 Governing Its Distinct Optical Emissions

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recommendations! Published in 2018 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201704210

Abstract: Defects and their spatial distribution are crucial factors in controlling the electronic and optical properties of semiconductors. By using scanning transmission electron microscopy and electron energy loss spectroscopy, the type of impurities/defects in WS2 subdomains… read more here.

Keywords: atomic defects; defects ws2; optical properties; revealing atomic ... See more keywords

Manipulation of Conductive Domain Walls in Confined Ferroelectric Nanoislands

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recommendations! Published in 2019 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201807276

Abstract: Conductive ferroelectric domain walls--ultra-narrow and configurable conduction paths, have been considered as essential building blocks for future programmable domain wall electronics. For applications in high density devices, it is imperative to explore the conductive domain… read more here.

Keywords: walls confined; manipulation conductive; conductive domain; domain ... See more keywords