Crystal structure of the catalytic D2 domain of the AAA+ ATPase p97 reveals a putative helical split‐washer‐type mechanism for substrate unfolding
Sign Up to like & getrecommendations! Published in 2019 at "Febs Letters"
DOI: 10.1002/1873-3468.13667
Abstract: Several pathologies have been associated with the AAA+ ATPase p97, an enzyme essential to protein homeostasis. Heterozygous polymorphisms in p97 have been shown to cause neurological disease, while elevated proteotoxic stress in tumours has made… read more here.
Keywords: mechanism; atpase p97; p97; aaa atpase ... See more keywords
Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13791
Abstract: Neurofibrillary tangles formed by abnormally aggregated tau protein are a histopathological feature of tauopathies. A tau aggregation inhibitor is a potential therapeutic agent for tauopathies. In this study, we prepared a monoclonal antibody for tau,… read more here.
Keywords: tau aggregation; crystal structure; domain; monoclonal antibody ... See more keywords
The T1‐tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel
Sign Up to like & getrecommendations! Published in 2022 at "Febs Letters"
DOI: 10.1002/1873-3468.14279
Abstract: Cytoplasmic domains frequently promote functional assembly of multimeric ion channels. To investigate structural determinants of this process, we generated the ‘T1‐chimera’ construct of the NaChBac sodium channel by truncating its C‐terminal domain and splicing the… read more here.
Keywords: nachbac sodium; sodium channel; domain; channel ... See more keywords
TRAF trimers form immune signalling networks via RING domain dimerization
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14530
Abstract: For many inflammatory cytokines, the response elicited is dependent on the recruitment of the tumour necrosis factor receptor‐associated factor (TRAF) family of adaptor proteins. All TRAF proteins have a trimeric C‐terminal TRAF domain, while at… read more here.
Keywords: traf trimers; domain; ring domain; trimers form ... See more keywords
A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14632
Abstract: Copper radical oxidases (CROs) are redox enzymes able to oxidize alcohols or aldehydes, while only requiring a single copper atom as cofactor. Studied CROs are found in one of two subfamilies within the Auxiliary Activities… read more here.
Keywords: alcohol oxidase; burkholderia pseudomallei; domain;
Combination therapy with androgen receptor N‐terminal domain antagonist EPI‐7170 and enzalutamide yields synergistic activity in AR‐V7‐positive prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12770
Abstract: Resistance of castration‐resistant prostate cancer (CRPC) to enzalutamide and abiraterone involves the expression of constitutively active, truncated androgen receptor (AR) splice variants (AR‐Vs) that lack a C‐terminal ligand‐binding domain (LBD). Both full‐length AR and truncated… read more here.
Keywords: enzalutamide; prostate cancer; domain; epi 7170 ... See more keywords
PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12175
Abstract: Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric truncated form of the… read more here.
Keywords: hpah; regulatory domain; phenylalanine; phenylalanine hydroxylase ... See more keywords
Bovine natural antibody IgM inhibits the binding of human norovirus protruding domain to its HBGA receptors
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13450
Abstract: Human norovirus (HuNoV) is the primary viral pathogen that causes acute gastroenteritis (AGE) in humans. The protruding (P) domain of HuNoV interacts with cell surface histo‐blood group antigens (HBGAs) to initiate infection. Owing to the… read more here.
Keywords: natural antibody; hbga receptors; protruding domain; domain ... See more keywords
Revealing the Atomic Defects of WS2 Governing Its Distinct Optical Emissions
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201704210
Abstract: Defects and their spatial distribution are crucial factors in controlling the electronic and optical properties of semiconductors. By using scanning transmission electron microscopy and electron energy loss spectroscopy, the type of impurities/defects in WS2 subdomains… read more here.
Keywords: atomic defects; defects ws2; optical properties; revealing atomic ... See more keywords
Manipulation of Conductive Domain Walls in Confined Ferroelectric Nanoislands
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201807276
Abstract: Conductive ferroelectric domain walls--ultra-narrow and configurable conduction paths, have been considered as essential building blocks for future programmable domain wall electronics. For applications in high density devices, it is imperative to explore the conductive domain… read more here.
Keywords: walls confined; manipulation conductive; conductive domain; domain ... See more keywords
Ultrathin Polydopamine Films with Phospholipid Nanodiscs Containing a Glycophorin A Domain
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202000378
Abstract: Cellular membranes have long served as an inspiration for nanomaterial research. The preparation of ultrathin polydopamine (PDA) films with integrated protein pores containing phospholipids and an embedded domain of a membrane protein glycophorin A as… read more here.
Keywords: cellular membranes; membrane; glycophorin; domain ... See more keywords