Pharmacokinetic, Pharmacodynamic, and Safety Profile of a Novel Anti‐CD28 Domain Antibody Antagonist in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.791
Abstract: We report pharmacokinetics, pharmacodynamics, and safety of a novel anti‐CD28 domain antibody antagonist (lulizumab pegol) in healthy subjects following single‐ or multiple‐dose administration. A minimal anticipated biological effect level approach was used to select a… read more here.
Keywords: antibody antagonist; anti cd28; novel anti; domain antibody ... See more keywords
Site-Specific Radiohalogenation of a HER2-Targeted Single-Domain Antibody Fragment Using a Novel Residualizing Prosthetic Agent.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01331
Abstract: Because of their rapid tumor accumulation and normal tissue clearance, single-domain antibody fragments (sdAbs) are an attractive vehicle for developing radiotherapeutics labeled with the α-emitter 211At. Herein, we have evaluated iso-[211At]AGMB-PODS, a prosthetic agent that… read more here.
Keywords: single domain; domain antibody; pods 5f7ggc; agmb pods ... See more keywords
Single-Domain Antibody-Functionalized pH-Responsive Amphiphilic Block Copolymer Nanoparticles for Epidermal Growth Factor Receptor Targeted Cancer Therapy
Sign Up to like & getrecommendations! Published in 2018 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.8b00461
Abstract: Biocompatible antibody–nanoparticle conjugates have attracted interest as anticancer agents due to their potential to selectively target therapeutic agents at disease sites. However, new formulation and conjugation approaches are urgently needed to improve their uniformity for… read more here.
Keywords: domain antibody; antibody; block copolymer; single domain ... See more keywords
Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15736
Abstract: Protein S (PS) is a natural anticoagulant acting as a cofactor for activated protein C (APC) in the proteolytic inactivation of activated factors V (FVa) and VIII (FVIIIa), but also for tissue factor pathway inhibitor… read more here.
Keywords: activated protein; potential single; domain antibody; cofactor ... See more keywords
Natural Single-Domain Antibody-Nanobody: A Novel Concept in the Antibody Field.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2018.2463
Abstract: Since the serendipitous discovery of heavy-chain antibodies in Camelidae 20 years ago, the smallest single-domain antigen-binding fragment, known as VHH or nanobody, has received growing attention. In comparison with traditional antibodies, VHHs performs equally high… read more here.
Keywords: nanobody; antibody; natural single; single domain ... See more keywords
A single-domain antibody inhibits SFTSV and mitigates virus-induced pathogenesis in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.136855
Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that recently emerged in East Asian countries. SFTS is characterized by high fever, thrombocytopenia, leukopenia, multiorgan failure, and hemorrhage with case fatality rates… read more here.
Keywords: vivo; antibody inhibits; single domain; inhibits sftsv ... See more keywords
Phage displayed domain antibody mimics for pyrethroid and its application in immunoassay
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Agricultural and Biological Engineering"
DOI: 10.25165/ijabe.v13i2.5492
Abstract: Anti-idiotypic antibodies which can mimic antigens have many potential applications in the immunoassay. This research used the monoclonal antibody of the conserved chemical region of pyrethroids, 3-phenoxybenzoic acid (PBA), and the domain antibody library to… read more here.
Keywords: domain antibody; immunoassay; phage displayed; antibody ... See more keywords