X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.08.004
Abstract: Mechanisms establishing higher-order chromosome structures and their roles in gene regulation are elusive. We analyzed chromosome architecture during nematode X chromosome dosage compensation, which represses transcription via a dosage-compensation condensin complex (DCC) that binds hermaphrodite… read more here.
Keywords: dosage compensation; chromosome; domain architecture;
Introduction of bifunctionality in the multi-domain architecture of the ω-ester containing peptide plesiocin.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00803
Abstract: Modular biosynthetic pathway of ribosomally synthesized and post-translationally modified peptides (RiPPs) boosts their engineering potential for exploring new structures and biological functions. The ω-ester containing peptides (OEPs), a subfamily of RiPPs, have distinct side-to-side ester… read more here.
Keywords: ester containing; multi domain; domain; domain architecture ... See more keywords
Simulating domain architecture evolution
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac242
Abstract: Abstract Motivation Simulation is an essential technique for generating biomolecular data with a ‘known’ history for use in validating phylogenetic inference and other evolutionary methods. On longer time scales, simulation supports investigations of equilibrium behavior… read more here.
Keywords: simulation; domain; architecture evolution; domain architecture ... See more keywords
The complex domain architecture of SAMD9 family proteins, predicted STAND-like NTPases, suggests new links to inflammation and apoptosis
Sign Up to like & getrecommendations! Published in 2017 at "Biology Direct"
DOI: 10.1186/s13062-017-0185-2
Abstract: We report a comprehensive computational dissection of the domain architecture of the SAMD9 family proteins that are involved in antivirus and antitumor response in humans. We show that the SAMD9 protein family is represented in… read more here.
Keywords: domain architecture; samd9 family; family; family proteins ... See more keywords