An array of basic residues is essential for the nucleolytic activity of the PHP domain of bacterial/archaeal PolX DNA polymerases
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DOI: 10.1038/s41598-019-46349-8
Abstract: Bacterial/archaeal family X DNA polymerases (PolXs) have a C-terminal PHP domain with an active site formed by nine histidines and aspartates that catalyzes 3′-5′ exonuclease, AP-endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities. Multiple sequence alignments have allowed… read more here.
Keywords: bacterial archaeal; domain bacterial; dna polymerases; php domain ... See more keywords