The WW1 domain enhances auto-inhibition in Smurf ubiquitin ligases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.018
Abstract: Down-regulation of ubiquitin (Ub) ligase activity prevents premature ubiquitination and is critical for cellular homeostasis. Nedd4 Ub ligases share a common domain architecture and yet are regulated in distinct ways through interactions of the catalytic… read more here.
Keywords: domain enhances; hect domain; inhibition; enhances auto ... See more keywords
Dynamic rotation of the protruding domain enhances the infectivity of norovirus
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008619
Abstract: Norovirus is the major cause of epidemic nonbacterial gastroenteritis worldwide. Lack of structural information on infection and replication mechanisms hampers the development of effective vaccines and remedies. Here, using cryo-electron microscopy, we show that the… read more here.
Keywords: domain enhances; protruding domain; enhances infectivity; dynamic rotation ... See more keywords