Mapping the FF domain folding pathway via structures of transiently populated folding intermediates
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2416682121
Abstract: Significance Many protein molecules fold into well-defined functional structures. Although machine learning approaches enable accurate prediction of many of these structures, the mechanisms by which they fold remain elusive. Using solution NMR spectroscopy, we describe… read more here.
Keywords: pathway via; via structures; mapping domain; domain folding ... See more keywords
Structural perturbations on huntingtin N17 domain during its folding on 2D-nanomaterials.
Sign Up to like & getrecommendations! Published in 2017 at "Nanotechnology"
DOI: 10.1088/1361-6528/aa7ba5
Abstract: A globular protein's folded structure in its physiological environment is largely determined by its amino acid sequence. Recently, newly discovered transformer proteins as well as intrinsically disordered proteins may adopt the folding-upon-binding mechanism where their… read more here.
Keywords: huntingtin n17; perturbations huntingtin; domain folding; n17 domain ... See more keywords
Abstract Mo122: Investigating the Role of the Lysine Methyltransferase SMYD1 in Striated Muscle Motor Domain Folding
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.mo122
Abstract: Properly coordinated folding and assembly of myosin into the sarcomere thick filament is critical for cardiac and skeletal muscle development, function, growth, and maintenance. The motor domain of myosin heavy chain (MHC) requires muscle-specific chaperones… read more here.
Keywords: muscle; smyd1; domain folding; motor domain ... See more keywords