Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.02.111
Abstract: General control nonderepressible 2 (GCN2) is a serine/threonine protein kinase, detecting a variety of stresses including amino acid starvation, reactive oxygen species, etc. in eukaryotic cells. Activation of GCN2 requires the interaction of the N-terminal… read more here.
Keywords: dimer; crystal structures; rwd domain; domain ... See more keywords
Intrinsically disordered regions of the DNA-binding domain of human FoxP1 facilitate domain swapping.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.07.017
Abstract: Forkhead box P (FoxP) proteins are unique transcription factors that spatiotemporally regulate gene expression by tethering two chromosome loci together via functional domain-swapped dimers formed through their DNA-binding domains. Further, the differential kinetics on this… read more here.
Keywords: binding domain; human foxp1; dna binding; domain swapping ... See more keywords
Site‐specific Heterogeneity of Multi‐domain Human Serum Albumin and its Origin: A Red Edge Excitation Shift Study†
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and Photobiology"
DOI: 10.1111/php.13712
Abstract: Conformational heterogeneity is a defining characteristic of a protein and is vital in understanding its function and folding landscape. In the present work, we interrogated the presence of conformational heterogeneity in multi‐domain human serum albumin… read more here.
Keywords: heterogeneity; domain human; domain; human serum ... See more keywords