Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions
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DOI: 10.1002/ccs3.12014
Abstract: Abstract Protein–protein interactions (PPIs) play a crucial role in various biological processes by establishing domain–motif (DMI) and domain–domain interactions (DDIs). While the existence of real DMIs/DDIs is generally assumed, it is rarely tested; therefore, this… read more here.
Keywords: domain interactions; domain domain; domain motif; dmis ddis ... See more keywords
Domain interactions determine the conformational ensemble of the periplasmic chaperone SurA
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DOI: 10.1002/pro.3924
Abstract: SurA is thought to be the most important periplasmic chaperone for outer membrane protein (OMP) biogenesis. Its structure is composed of a core region and two peptidylprolyl isomerase domains, termed P1 and P2, connected by… read more here.
Keywords: conformational ensemble; sura; domain interactions; domain ... See more keywords
Erratum: Inferring domain of interactions among particles from ensemble of trajectories [Phys. Rev. E 102, 012404 (2020)].
Sign Up to like & getrecommendations! Published in 2020 at "Physical Review E"
DOI: 10.1103/physreve.102.069902
Abstract: This corrects the article DOI: 10.1103/PhysRevE.102.012404. read more here.
Keywords: among particles; interactions among; erratum inferring; domain interactions ... See more keywords
Centrosome maturation requires phosphorylation-mediated sequential domain interactions of SPD-5.
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DOI: 10.1242/jcs.259025
Abstract: Centrosomes consist of two centrioles and surrounding pericentriolar material (PCM). PCM expands during mitosis in a process called centrosome maturation, in which PCM scaffold proteins play pivotal roles to recruit other centrosomal proteins. In C.… read more here.
Keywords: domain interactions; sequential domain; domain; phosphorylation ... See more keywords
Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation
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DOI: 10.1371/journal.pone.0221256
Abstract: HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting its globular subdomains. It is compact when in solution but assumes an extended conformation when assembled within the immature HIV-1 virion. Here, we… read more here.
Keywords: gag; hiv gag; cactd; domain interactions ... See more keywords
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
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DOI: 10.15252/msb.20178129
Abstract: A key function of reversible protein phosphorylation is to regulate protein–protein interactions, many of which involve short linear motifs (3–12 amino acids). Motif‐based interactions are difficult to capture because of their often low‐to‐moderate affinities. Here,… read more here.
Keywords: motif based; phospho; domain interactions; phosphorylation ... See more keywords
Alternative ATPase domain interactions in eukaryotic Hsp70 chaperones
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DOI: 10.3389/fmolb.2023.1155784
Abstract: Hsp70 molecular chaperones are essential components for maintaining protein homeostasis within cells. They interact with substrate or client proteins in a well characterised fashion that is regulated by ATP and supported by co-chaperones. In eukaryotes… read more here.
Keywords: alternative atpase; atpase domain; domain interactions; atpase ... See more keywords