Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017406117
Abstract: Significance Necroptosis is an emergency controlled cell-death mechanism, which only may be activated in case of impaired apoptosis. Necroptosis leads to unchecked release of proinflammatory cytoplasmatic content of the cells and is thereby implicated in… read more here.
Keywords: necroptosis; kinase domain; like protein; domain like ... See more keywords
Decrease in fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain‐like pseudokinase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14740
Abstract: Receptor‐interacting serine/threonine kinase 3 and mixed lineage kinase domain‐like pseudokinase (MLKL) have gained attention as apoptosis alternate cell death signaling molecules. We aimed to evaluate the role of MLKL in non‐alcoholic fatty liver disease (NAFLD). read more here.
Keywords: non alcoholic; kinase domain; like pseudokinase; domain like ... See more keywords
Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates
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DOI: 10.1371/journal.pone.0194938
Abstract: Introduction Down syndrome (DS) is the most frequent genetic cause of intellectual disability. Despite the fact that more than 50 years have passed since the discovery of its genetic aberrations, the exact pathogenesis of the… read more here.
Keywords: methylation; model; blood; domain like ... See more keywords