The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
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DOI: 10.1016/j.nbd.2019.104614
Abstract: The G2019S substitution in the kinase domain of LRRK2 (LRRK2G2019S) is the most prevalent mutation associated with Parkinson's disease (PD). Neurotoxic effects of LRRK2G2019S are thought to result from an increase in its kinase activity… read more here.
Keywords: terminal domain; domain lrrk2; neurons vivo; kinase ... See more keywords