Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
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DOI: 10.1038/s41467-022-29585-x
Abstract: PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report… read more here.
Keywords: domain mutant; helical domain; domain mutation; pik3ca helical ... See more keywords