Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29585-x
Abstract: PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110α, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report… read more here.
Keywords: domain mutant; helical domain; domain mutation; pik3ca helical ... See more keywords
EGFR extracellular domain mutation in patients with lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e20532
Abstract: e20532 Background: Missense mutations in the EGFR extracellular (EC) domain are found in 10% to 15% of glioblastomas(GBM). However, little is known about EGFR EC domain mutations in lung cancer. In this study, we retrospectively… read more here.
Keywords: lung cancer; domain mutation; egfr; domain ... See more keywords