Characteristics and outcome of chronic myeloid leukemia patients with E255K/V BCR–ABL kinase domain mutations
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DOI: 10.1007/s12185-018-2422-6
Abstract: Kinase domain (KD) mutations of ABL1 represent the most common resistance mechanism to tyrosine kinase inhibitors (TKI) in CML. Besides T315I, mutations in codon 255 are highly resistant mutations in vitro to all TKI. We… read more here.
Keywords: kinase domain; patients e255k; response; domain mutations ... See more keywords
PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment
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DOI: 10.1038/leu.2017.110
Abstract: PLCG2 C2 domain mutations co-occur with BTK and PLCG2 resistance mutations in chronic lymphocytic leukemia undergoing ibrutinib treatment read more here.
Keywords: plcg2; occur btk; mutations occur; domain mutations ... See more keywords
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks
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DOI: 10.3390/genes13030413
Abstract: Hepatocyte nuclear factor 1A (HNF1A) is the master regulator of liver homeostasis and organogenesis and regulates many aspects of hepatocyte functions. It acts as a tumor suppressor in the liver, evidenced by the increased proliferation… read more here.
Keywords: hnf4a; domain mutations; hnf1a pou; pou domain ... See more keywords