Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136494
Abstract: The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channel, TREK1, TREK2 and TRAAK… read more here.
Keywords: pain; two pore; pore domain; domain potassium ... See more keywords
The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci95945
Abstract: Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known. We identified a K2P gene, CG8713 (sandman), in a Drosophila genetic screen and… read more here.
Keywords: dysfunction; two pore; pore domain; domain potassium ... See more keywords
Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels.
Sign Up to like & getrecommendations! Published in 2021 at "Current neuropharmacology"
DOI: 10.2174/1570159x19666210407152528
Abstract: Two-pore domain potassium (K2P) channels are a diverse family of potassium channels. K2P channels generate background leak potassium currents to regulate cellular excitability and are thereby involved in a wide range of neurological disorders. K2P… read more here.
Keywords: potassium; domain potassium; k2p channels; potassium channels ... See more keywords