Role of Bin‐Amphiphysin‐Rvs (BAR) domain proteins in mediating neuronal signaling and disease
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22248
Abstract: Several proteins contain signaling domains that can regulate the cell membrane dynamics as well as the underlying cytoskeleton. Among these, Bin‐Amphiphysin‐Rvs (BAR) domain‐containing proteins, with their membrane deforming properties, have emerged as the key players… read more here.
Keywords: bin amphiphysin; bar domain; bar; amphiphysin rvs ... See more keywords
J-Domain Proteins in Bacteria and their Viruses.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.04.014
Abstract: Molecular chaperones maintain cellular protein homeostasis by acting at almost every step in protein biogenesis pathways. The DnaK/HSP70 chaperone has been associated with almost every known essential chaperone functions in bacteria. To act as a… read more here.
Keywords: proteins bacteria; dnak; domain proteins; bacteria viruses ... See more keywords
HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.12.009
Abstract: Bacteria are continually challenged by foreign invaders, including bacteriophages, and have evolved a variety of defenses against these invaders. Here, we describe the structural and biochemical mechanisms of a bacteriophage immunity pathway found in a… read more here.
Keywords: bacteriophage; atpase; domain proteins; horma domain ... See more keywords
Coarse-Grained Modeling of Multiple Pathways in Conformational Transitions of Multi-Domain Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00286
Abstract: Large-scale conformational transitions in multi-domain proteins are often essential for their functions. To investigate the transitions, it is necessary to explore multiple potential pathways, which involve different intermediate structures. Here, we present a multi-basin (MB)… read more here.
Keywords: domain proteins; transitions multi; coarse grained; multi domain ... See more keywords
Identification of subfunctionalized aggregate-remodeling J-domain proteins in Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac514
Abstract: J-domain proteins (JDPs) are critical components of the cellular protein quality control machinery, playing crucial roles in preventing the formation and solubilizing cytotoxic protein aggregates. Bacteria, yeast and plants additionally have large, multimeric Hsp100-class disaggregases… read more here.
Keywords: aggregate remodeling; arabidopsis thaliana; protein aggregates; domain proteins ... See more keywords
SlVQ15 Interacts with Jasmonate-ZIM Domain Proteins and SlWRKY31 to Regulate Defense Response in Tomato.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac275
Abstract: Botrytis cinerea is one of the most widely distributed and harmful pathogens worldwide. Both the phytohormone jasmonate (JA) and the VQ motif-containing proteins play crucial roles in plant resistance to B. cinerea. However, their crosstalk… read more here.
Keywords: cinerea; slvq15; zim domain; resistance cinerea ... See more keywords
Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0197621
Abstract: LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements. Most human cells contain two SUN proteins, Sun1 and… read more here.
Keywords: linc complexes; domain proteins; linc; gene expression ... See more keywords
Widespread evolutionary crosstalk among protein domains in the context of multi-domain proteins
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0203085
Abstract: Domains are distinct units within proteins that typically can fold independently into recognizable three-dimensional structures to facilitate their functions. The structural and functional independence of protein domains is reflected by their apparent modularity in the… read more here.
Keywords: context multi; domain proteins; protein domains; multi domain ... See more keywords
A redox-active crosslinker reveals an essential and inhibitable oxidative folding network in the endoplasmic reticulum of malaria parasites
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009293
Abstract: Malaria remains a major global health problem, creating a constant need for research to identify druggable weaknesses in P. falciparum biology. As important components of cellular redox biology, members of the Thioredoxin (Trx) superfamily of… read more here.
Keywords: malaria; domain proteins; endoplasmic reticulum; biology ... See more keywords
LOTUS-domain proteins - developmental effectors from a molecular perspective.
Sign Up to like & getrecommendations! Published in 2020 at "Biological chemistry"
DOI: 10.1515/hsz-2020-0270
Abstract: The LOTUS domain (also known as OST-HTH) is a highly conserved protein domain found in a variety of bacteria and eukaryotes. In animals, the LOTUS domain is present in the proteins Oskar, TDRD5/Tejas, TDRD7/TRAP/Tapas, and… read more here.
Keywords: domain proteins; developmental effectors; proteins developmental; lotus domain ... See more keywords
Enzymatic properties of CARF-domain proteins in Synechocystis sp. PCC 6803
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1046388
Abstract: Prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated genes) systems provide immunity against invading genetic elements such as bacteriophages and plasmids. In type III CRISPR systems, the recognition of target RNA leads to… read more here.
Keywords: carf domain; pcc 6803; crispr; domain ... See more keywords