Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14522
Abstract: The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen… read more here.
Keywords: discoidin domain; domain receptor; erbb3 signaling; receptor ... See more keywords
Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103162
Abstract: Background Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by collagens that is involved in the pathogenesis of fibrotic disorders. Interestingly, de novo production of the collagen type I (Col… read more here.
Keywords: alport syndrome; receptor; discoidin domain; domain receptor ... See more keywords
Macrocyclization: Enhancing Drug-like Properties of Discoidin Domain Receptor Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2025 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.4c00611
Abstract: Macrocyclization, a well-established strategy for developing ligands against challenging drug targets, was employed to design macrocyclic alternatives to a linear discoidin domain receptor (DDR) inhibitor (1) with potential applications in treating fibrotic diseases. This study… read more here.
Keywords: drug like; drug; domain receptor; discoidin domain ... See more keywords
Control of craniofacial development by the collagen receptor, discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.03.479017
Abstract: Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in discoidin domain receptor 2 (DDR2), a non-integrin collagen receptor,… read more here.
Keywords: discoidin domain; domain receptor; development; collagen ... See more keywords
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00388-y
Abstract: Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor… read more here.
Keywords: wound healing; c1q; ddr2; domain receptor ... See more keywords
Discoidin Domain Receptor 1 in Colonic Epithelial Cells: A Paracrine Driver of Colonic Fibrosis.
Sign Up to like & getrecommendations! Published in 2025 at "Current pharmaceutical biotechnology"
DOI: 10.2174/0113892010418561250917063533
Abstract: INTRODUCTION This study investigated the role and potential mechanisms of discoidin domain receptor 1 (DDR1) in colon fibrogenesis. METHODS We employed the DSS-induced chronic colitis and fibrosis model to evaluate the therapeutic potential of DDR1… read more here.
Keywords: fibrosis; discoidin domain; ddr1; colonic epithelial ... See more keywords
152-LB: Sodium-Glucose Cotransporter Inhibitor Impairs Adhesion of Cancer Cells by Increasing Shedding and Dephosphorylation of Discoid Domain Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-152-lb
Abstract: Dapagliflozin, a selective inhibitor of the sodium/glucose cotransporter 2 (SGLT2), is used clinically to reduce circulating glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose from the kidney. Dapagliflozin… read more here.
Keywords: adhesion; sodium glucose; dapagliflozin; glucose cotransporter ... See more keywords
Discoidin domain receptor 1 as a promising biomarker for high-grade gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_708_21
Abstract: Background: Two fundamental challenges in the current therapeutic approach for central nervous system tumors are the tumor heterogeneity and the absence of specific treatments and biomarkers that selectively target the tumor tissue. Therefore, we aimed… read more here.
Keywords: discoidin domain; domain receptor; serum; ddr1 expression ... See more keywords