Discoidin domain receptor 1 regulates ErbB2/ErbB3 signaling in mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14522
Abstract: The ErbB2 receptor tyrosine kinase plays a key role in mammary gland development. It forms large clusters which serve as signaling platforms for integration of extracellular information. The discoidin domain receptor (DDR) family are collagen… read more here.
Keywords: discoidin domain; domain receptor; erbb3 signaling; receptor ... See more keywords
Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103162
Abstract: Background Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by collagens that is involved in the pathogenesis of fibrotic disorders. Interestingly, de novo production of the collagen type I (Col… read more here.
Keywords: alport syndrome; receptor; discoidin domain; domain receptor ... See more keywords
Control of craniofacial development by the collagen receptor, discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.02.03.479017
Abstract: Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in discoidin domain receptor 2 (DDR2), a non-integrin collagen receptor,… read more here.
Keywords: discoidin domain; domain receptor; development; collagen ... See more keywords
The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00388-y
Abstract: Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor… read more here.
Keywords: wound healing; c1q; ddr2; domain receptor ... See more keywords
152-LB: Sodium-Glucose Cotransporter Inhibitor Impairs Adhesion of Cancer Cells by Increasing Shedding and Dephosphorylation of Discoid Domain Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-152-lb
Abstract: Dapagliflozin, a selective inhibitor of the sodium/glucose cotransporter 2 (SGLT2), is used clinically to reduce circulating glucose levels in patients with type 2 diabetes mellitus by blocking the reabsorption of glucose from the kidney. Dapagliflozin… read more here.
Keywords: adhesion; sodium glucose; dapagliflozin; glucose cotransporter ... See more keywords
Discoidin domain receptor 1 as a promising biomarker for high-grade gliomas
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_708_21
Abstract: Background: Two fundamental challenges in the current therapeutic approach for central nervous system tumors are the tumor heterogeneity and the absence of specific treatments and biomarkers that selectively target the tumor tissue. Therefore, we aimed… read more here.
Keywords: discoidin domain; domain receptor; serum; ddr1 expression ... See more keywords