Virtual Screening of Phytochemicals by Targeting HR1 Domain of SARS-CoV-2 S Protein: Molecular Docking, Molecular Dynamics Simulations, and DFT Studies
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DOI: 10.1155/2021/6661191
Abstract: The recent COVID-19 pandemic has impacted nearly the whole world due to its high morbidity and mortality rate. Thus, scientists around the globe are working to find potent drugs and designing an effective vaccine against… read more here.
Keywords: molecular dynamics; domain sars; hr1 domain; sars cov ... See more keywords
Suramin Disturbs the Association of the N-Terminal Domain of SARS-CoV-2 Nucleocapsid Protein with RNA
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DOI: 10.3390/molecules28062534
Abstract: Suramin was originally used as an antiparasitic drug in clinics. Here, we demonstrate that suramin can bind to the N-terminal domain of SARS-CoV-2 nucleocapsid protein (N-NTD) and disturb its interaction with RNA. The BLI experiments… read more here.
Keywords: nucleocapsid protein; suramin; terminal domain; cov nucleocapsid ... See more keywords