Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer.
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DOI: 10.1182/blood.2020009440
Abstract: GPVI is the major signalling receptor for collagen on platelets. We have raised 54 nanobodies (Nb), grouped into 33 structural classes based on their complementary determining region 3 (CDR3) loops, against recombinant GPVI-Fc (dimeric GPVI)… read more here.
Keywords: collagen; domain swapped; domain swap; recombinant gpvi ... See more keywords