Engineered domain swapping indicates context dependent functional role of RNA G-quadruplexes.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.03.007
Abstract: RNA domain swapping typically demonstrates conservation of the native function of the domain in a non-native context. In contrast, we employed RNA engineering to demonstrate deviation of G-quadruplex (GQ) function that is contingent upon its… read more here.
Keywords: rna; context dependent; functional role; domain swapping ... See more keywords
Oligomerization of cytochrome c, myoglobin, and related heme proteins by 3D domain swapping.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2019.03.002
Abstract: Oligomerization of heme proteins is useful for construction of new materials with cooperative and systematic functions; thus, diverse methods have been applied for construction of artificial heme protein oligomers. Three-dimensional (3D) domain swapping is a… read more here.
Keywords: heme; oligomerization cytochrome; heme proteins; proteins domain ... See more keywords
Intrinsically disordered regions of the DNA-binding domain of human FoxP1 facilitate domain swapping.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.07.017
Abstract: Forkhead box P (FoxP) proteins are unique transcription factors that spatiotemporally regulate gene expression by tethering two chromosome loci together via functional domain-swapped dimers formed through their DNA-binding domains. Further, the differential kinetics on this… read more here.
Keywords: binding domain; human foxp1; dna binding; domain swapping ... See more keywords
A five-residue motif for the design of domain swapping in proteins
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.2210/pdb6iwj/pdb
Abstract: Domain swapping is the process by which identical monomeric proteins exchange structural elements to generate dimers/oligomers. Although engineered domain swapping is a compelling strategy for protein assembly, its application has been limited due to the… read more here.
Keywords: swapping proteins; domain swapping; domain; motif ... See more keywords
Human FoxP Transcription Factors as Tractable Models of the Evolution and Functional Outcomes of Three-Dimensional Domain Swapping
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910296
Abstract: The association of two or more proteins to adopt a quaternary complex is one of the most widespread mechanisms by which protein function is modulated. In this scenario, three-dimensional domain swapping (3D-DS) constitutes one plausible… read more here.
Keywords: three dimensional; human foxp; dimensional domain; domain swapping ... See more keywords