LAUSR

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

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0 Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b00659

Abstract: Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the "assembly line" biosynthesis of many genetically encoded small molecules. Site-directed mutagenesis, protein biochemical, and structural studies have focused on… read more here.

Keywords: targeted metabolomics; multidomain; domain targeted; colibactin biosynthesis ... See more keywords