Domain unfolding of monoclonal antibody fragments revealed by non-reducing SDS-PAGE
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2018.10.004
Abstract: Monoclonal antibodies and derived fragments are used extensively both experimentally and therapeutically. Thorough characterization of such antibodies is necessary and includes assessment of their thermal and storage stabilities. Thus, assessment of the underlying conformational stabilities… read more here.
Keywords: reducing sds; non reducing; antibody; sds page ... See more keywords
Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.09.001
Abstract: Using Brownian molecular dynamics simulations, we examine the internal dynamics and biomechanical response of von Willebrand factor (vWF) multimers subject to shear flow. The coarse grain multimer description employed here is based on a monomer… read more here.
Keywords: shear flow; force; von willebrand; willebrand factor ... See more keywords