Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition.
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DOI: 10.1016/j.jmb.2017.12.011
Abstract: Pleckstrin homology (PH) domains mediate protein-membrane interactions by binding to phosphatidylinositol phosphate (PIP) molecules. The structural and energetic basis of selective PH-PIP interactions is central to understanding many cellular processes, yet the molecular complexities of… read more here.
Keywords: biochemistry; homology domains; pleckstrin homology; membrane recognition ... See more keywords