Multiple mutations on α, β and γ domains of streptokinase lead to the generation of highly efficient cysteine analogues with promising features.
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DOI: 10.2174/1389201024666221124151623
Abstract: BACKGROUND Streptokinase, one of the most widely used thrombolytic medicines, is a favorable protein for site-specific PEGylation as it lacks any cysteine residues in its amino acid sequence; however, any changes in the protein´s structure… read more here.
Keywords: multiple mutations; mutations domains; cysteine analogues; activity ... See more keywords