Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study
Sign Up to like & getrecommendations! Published in 2022 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(21)00375-6
Abstract: BACKGROUND Insights gained from studying individuals with autosomal dominant Alzheimer's disease have broadly influenced mechanistic hypotheses, biomarker development, and clinical trials in both sporadic and dominantly inherited Alzheimer's disease. Although pathogenic variants causing autosomal dominant… read more here.
Keywords: pib pet; alzheimer disease; disease; dominant alzheimer ... See more keywords
Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab166
Abstract: Abstract In vitro studies of autosomal dominant Alzheimer’s disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo. In this cross-sectional cohort study, we used… read more here.
Keywords: amyloid ratios; dominant alzheimer; autosomal dominant; disease ... See more keywords
Plasma biomarker profiles in autosomal dominant Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2023 at "Brain"
DOI: 10.1093/brain/awac399
Abstract: Abstract Emerging plasma biomarkers of Alzheimer's disease might be non-invasive tools to trace early Alzheimer's disease-related abnormalities such as the accumulation of amyloid-beta peptides, neurofibrillary tau tangles, glial activation and neurodegeneration. It is, however, unclear… read more here.
Keywords: disease; alzheimer disease; dominant alzheimer; plasma ... See more keywords
Subjective memory complaints in preclinical autosomal dominant Alzheimer disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000004533
Abstract: Objective: To cross-sectionally study subjective memory complaints (SMC) in autosomal dominant Alzheimer disease (ADAD). Methods: We examined self-reported and study partner–based SMC in 52 young, cognitively unimpaired individuals from a Colombian kindred with early-onset ADAD.… read more here.
Keywords: memory complaints; alzheimer disease; dominant alzheimer; autosomal dominant ... See more keywords