Modeling the Subclonal Evolution of Cancer Cell Populations.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1229
Abstract: Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected dynamics and extent to which these divergent subclonal expansions occur. Here, we… read more here.
Keywords: dominant clones; subclonal evolution; cancer cell; cancer ... See more keywords
B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1115361
Abstract: Introduction Chronic lymphocytic leukemia (CLL) is the most common adult leukemia, accounting for 30–40% of all adult leukemias. The dynamics of B-lymphocyte CLL clones with mutated immunoglobulin heavy chain variable region (IgHV) genes in their… read more here.
Keywords: dominant clones; replacement mutations; selection replacement; cll clones ... See more keywords