Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.
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DOI: 10.1172/jci.insight.96700
Abstract: Mutations in the ubiquitin ligase scaffold protein Cullin 3 (CUL3) cause the disease familial hyperkalemic hypertension (FHHt). In the kidney, mutant CUL3 (CUL3-Δ9) increases abundance of With-No-Lysine [K] Kinase 4 (WNK4), with excessive activation of… read more here.
Keywords: dominant effects; hyperkalemic hypertension; familial hyperkalemic; cul3 ... See more keywords