Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
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DOI: 10.1021/acs.jmedchem.2c00567
Abstract: Cyst formation and enlargement in autosomal dominant kidney disease (ADPKD) is mainly driven by aberrantly increased cytosolic cAMP in renal tubule epithelial cells. Because the vasopressin V2 receptor (V2R) regulates intracellular cAMP levels in kidneys,… read more here.
Keywords: dominant kidney; kidney; benzodiazepine derivatives; vasopressin receptor ... See more keywords