P4O10/TfOH mediated domino condensation–cyclization of amines with diacids: a route to indolizidine alkaloids under catalyst- and solvent-free conditions
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DOI: 10.1039/d2ra02534e
Abstract: A domino condensation–cyclization method is developed to synthesize indolizidine alkaloids using a P4O10/TfOH reagent system without the employment of either a catalyst or solvent. The use of a few aliphatic and aromatic dicarboxylic acids is… read more here.
Keywords: condensation cyclization; domino condensation; indolizidine alkaloids; p4o10 tfoh ... See more keywords
One-Pot Catalyst-Free Domino Condensation/Intramolecular 1,3-Dipolar Cycloaddition: Highly Stereoselective Access to Phosphadihydrocoumarin-Fused N,N-Bicyclic Pyrazolidin-3-ones
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DOI: 10.1055/s-0036-1590896
Abstract: A concise, atom-economic, and highly regio/stereoselective synthetic strategy was developed for the construction of phosphorus- and nitrogen-fused polycyclic skeleton derivatives. The one-pot, two-step, catalyst-free domino condensation/intramolecular cycloaddition reaction of various substituted 2-(vinylphosphoryloxy)benzaldehydes with pyrazolidin-3-one took… read more here.
Keywords: free domino; domino condensation; one pot; catalyst free ... See more keywords