Asymmetric Domino Heck Arylation and Alkylation of Nonconjugated Dienes: Double C-F···Sodium Attractive Noncovalent Interaction.
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DOI: 10.1021/acs.orglett.1c02457
Abstract: Palladium catalyzes a domino Heck arylation and alkylation of nonconjugated cyclodienes to produce trans isomers of disubstituted cyclohexenes in exceptionally high enantiomeric ratios, reaching 100:1 to 200:1 in many cases. Importantly, the interactions of the… read more here.
Keywords: arylation alkylation; heck arylation; domino heck; attractive noncovalent ... See more keywords
Highly Diastereoselective Synthesis of Oxindoles Containing Vicinal Quaternary and Tertiary Stereocenters by a Domino Heck/Decarboxylative Alkynylation Sequence.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01517
Abstract: A palladium-catalyzed domino Heck/decarboxylative alkynylation reaction of trisubstituted alkenes or enamines is reported. For two different types of substrates, the current domino reaction employing different solvents and bases led to 3,3-disubstituted oxindoles and hydropyrimidinyl spirooxindoles… read more here.
Keywords: vicinal quaternary; containing vicinal; domino heck; heck decarboxylative ... See more keywords
Palladium-Catalyzed Domino Heck/Aryne Carbopalladation/C-H Functionalization: Synthesis of Heterocycle-Fused 9,10-Dihydrophenanthrenes.
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DOI: 10.1021/acs.orglett.6b03833
Abstract: A novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using in situ generated arynes has been developed in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords moderate to excellent… read more here.
Keywords: carbopalladation functionalization; domino heck; palladium catalyzed; heck aryne ... See more keywords
Palladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03883
Abstract: A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br… read more here.
Keywords: heck activation; decarboxylation; domino heck; palladium catalyzed ... See more keywords