Phosphine-Catalyzed Dual Umpolung Domino Michael Reaction: Facile Synthesis of Hydroindole- and Hydrobenzofuran-2-Carboxylates
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DOI: 10.1021/acscatal.8b01011
Abstract: A highly atom-economical, chemoselective, and stereoselective Lewis base (LB)-catalyzed dual umpolung domino Michael reaction between cyclohexadienones and alkynyl esters has been developed. PPh3, as a LB catalyst, afforded either the hydroindole-2-carboxylates or hydrobenzofuran-2-carboxylates 3 as… read more here.
Keywords: umpolung domino; hydrobenzofuran carboxylates; domino michael; catalyzed dual ... See more keywords
Catalytic Asymmetric Domino Michael/Annulation Reaction of Bifunctional Chromone Synthons with β,γ-Unsaturated α-Keto Esters: Rapid Access to Polysubstituted Spirocyclic Hexahydroxanthones
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DOI: 10.1055/s-0040-1707340
Abstract: A thiourea-catalyzed asymmetric domino Michael/annulation process was devised employing bifunctional oxindole-chromones as C4 synthons and β,γ-unsaturated α-keto esters as C2 synthons. This reaction enables the highly diastereo- and enantioselective synthesis of a range of biologically… read more here.
Keywords: asymmetric domino; keto esters; domino michael; michael annulation ... See more keywords