Domino synthesis of quinazolin-4-yl thioureido alkanoates
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DOI: 10.1007/s11696-017-0273-x
Abstract: A simple convenient protocol for the synthesis of methyl 2-[3-(2-(substituted phenyl)quinazolin-4-yl)thioureido] alkanoates is described. It involves the domino reaction of various amino acid esters with imidoylisothiocyanates in ethyl acetate to afford quinazoline thiourea derivatives in… read more here.
Keywords: thioureido alkanoates; domino synthesis; quinazolin thioureido;
I2/TBHP mediated domino synthesis of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-aryl/alkyl benzamides and evaluation of their anticancer and docking studies
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DOI: 10.1039/d2ra02216h
Abstract: A novel I2/TBHP mediated domino synthesis of 2-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-phenyl benzamides by reaction of isatins with o-amino N-aryl/alkyl benzamides was described. This was the first application of o-amino N-aryl/alkyl benzamides participating in oxidative rearrangement with isatins for… read more here.
Keywords: tbhp mediated; domino synthesis; mediated domino; synthesis dioxo ... See more keywords