Four‐Way Crossover Phase 1 Thorough QT Study to Assess Cardiac Safety of Domperidone and Consideration for Design and Conduct of QT/QTc Study in China
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1072
Abstract: This study aimed to evaluate the QT prolongation potential of domperidone in healthy Chinese participants and explore the possibility of a thorough QT (TQT) study in China with a smaller sample size using concentration‐QT (C‐QT)… read more here.
Keywords: domperidone placebo; way crossover; domperidone; study china ... See more keywords
Pharmacokinetics and Bioequivalence of 2 Oral Formulations of Domperidone After Single‐Dose Administration in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1097
Abstract: To evaluate the pharmacokinetic properties and bioequivalence of 2 oral formulations of domperidone in healthy Chinese subjects, a randomized, open‐label, 2‐way crossover study was conducted under fasting and fed states. All 96 healthy subjects were… read more here.
Keywords: time; bioequivalence oral; domperidone; formulations domperidone ... See more keywords
Evaluation of domperidone efficacy to prevent aspiration pneumonia in patients with acute ischemic stroke: a randomized clinical trial.
Sign Up to like & getrecommendations! Published in 2022 at "Acta neurologica Belgica"
DOI: 10.1007/s13760-022-01925-0
Abstract: BACKGROUND AND AIM Aspiration pneumonia is an essential complication of acute ischemic stroke (AIS), which is responsible for increased three-fold mortality within a month. There is an interest towards the effect of prokinetics on prevention… read more here.
Keywords: domperidone; acute ischemic; stroke; pneumonia ... See more keywords
Awareness of, and Compliance with, Domperidone Revised Labeling After a Risk-Minimization Activity in Europe
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DOI: 10.1007/s40261-019-00831-3
Abstract: Background and ObjectiveRisk-minimization measures (RMM), including label revisions were implemented in Europe for domperidone because of evidence of increased incidence of cardiac arrhythmia and sudden cardiac death. In accordance with the guideline on good pharmacovigilance practices,… read more here.
Keywords: revised labeling; domperidone; compliance; risk minimization ... See more keywords
Solubility modelling and solvent effect for domperidone in twelve green solvents
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DOI: 10.1016/j.molliq.2018.03.121
Abstract: Abstract Solid solubility is a significant physical property for a drug development and design. In the present work, the domperidone solubility, which has less study in the near-term, was reported, which was determined by the… read more here.
Keywords: green solvents; solvent effect; twelve green; solubility ... See more keywords
Comparison of efficacy and safety of preventive measures used against canine leishmaniasis in southern European countries: Longitudinal retrospective study in 1647 client-owned dogs (2012-2016).
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2018.09.014
Abstract: The best preventive strategy for canine leishmaniasis is, to date, unknown. In the last few years, new preventive measures have become available in Europe, including vaccination against leishmaniasis and the use of domperidone. The objective… read more here.
Keywords: leishmaniasis; preventive measures; study; canine leishmaniasis ... See more keywords
Drugs in focus: Domperidone.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pediatric gastroenterology and nutrition"
DOI: 10.1097/mpg.0000000000003822
Abstract: Domperidone is a peripheral dopamine D2 receptor antagonist with prokinetic and antiemetic properties. Its prokinetic effects are mainly manifest in the upper gastrointestinal (GI) tract. Currently its use is restricted to relief of nausea and… read more here.
Keywords: drugs focus; efficacy; domperidone; gastroenterology ... See more keywords
P16 An audit of domperidone prescribing in children
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-314585.25
Abstract: Introduction/aim The European Medicines Agency (EMA) reviewed the use of domperidone containing medicines in March 2014, due to concerns about cardiac abnormalities. The Medicines and Healthcare products Regulatory Agency (MHRA) then responded and issued a… read more here.
Keywords: audit; drug safety; domperidone; domperidone prescribing ... See more keywords
Cardiac safety and clinical efficacy of high-dose domperidone for long-term treatment of gastroparesis symptoms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2021-001968
Abstract: Domperidone is an effective antiemetic used worldwide, but there have been reports of possible cardiotoxicity. Our goal was to explore the cardiac safety and clinical efficacy of long-term domperidone, titrated as high as 120 mg/day,… read more here.
Keywords: domperidone; long term; cardiac safety; efficacy ... See more keywords
Exploring the Prescribing Process of Domperidone for Low Milk Supply: A Qualitative Study Among Mothers, IBCLCs, and Family Doctors
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DOI: 10.1177/0890334420964070
Abstract: Background When mothers are confronted with milk supply problems, taking domperidone is regularly suggested. However, domperidone has been associated with sudden cardiac death and caution in prescribing is advised. In 2016, a multidisciplinary group of… read more here.
Keywords: domperidone; clinical protocol; milk supply; family ... See more keywords
Repurposing Domperidone in Secondary Progressive MS: A Simon 2-Stage Phase 2 Futility Trial
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DOI: 10.1212/wnl.0000000000011863
Abstract: Objective To assess whether treatment with the generic drug domperidone can reduce the progression of disability in secondary progressive multiple sclerosis (SPMS), we conducted a phase 2 futility trial following the Simon two-stage design. Methods… read more here.
Keywords: domperidone; futility; disability; futility trial ... See more keywords