Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical Research"
DOI: 10.1007/s11064-020-03107-x
Abstract: Obesity is characterized by chronic inflammation of low grade. The cholinergic anti-inflammatory pathway favors the reduction of the inflammatory response. In this work the effect of stimulation of the cholinergic anti-inflammatory pathway on SHIRPA behavioral… read more here.
Keywords: anti inflammatory; donepezil; donepezil prevents; inflammatory pathway ... See more keywords
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.09.057
Abstract: A novel series of donepezil based multi-functional agents "(E)-5,6-dimethoxy-2-(4-(4-substituted piperazin-1-yl)benzylidene)-2,3-dihydro-1H-inden-1-ones" have been designed and synthesized as potential anti-Alzheimer's agents. In-vitro studies revealed that these compounds demonstrated moderate to good AChE and Aβ aggregation inhibitory activity.… read more here.
Keywords: donepezil; alzheimer disease; multi functional; functional agents ... See more keywords
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114045
Abstract: Depression is one of the most frequent comorbid psychiatric symptoms of Alzheimer's disease (AD), and no efficacious drugs have been approved specifically for this purpose thus far. Herein, we proposed a novel therapeutic strategy that… read more here.
Keywords: depression; vilazodone donepezil; triple target; donepezil ... See more keywords
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114358
Abstract: Alzheimer's disease (AD) is a widespread multifactorial aging-related pathology, which includes cholinergic deficit among its main causes. Following a multi-target design strategy, the structure of the approved drug donepezil was taken as the starting point… read more here.
Keywords: donepezil; alzheimer disease; target; multi target ... See more keywords
Ionic liquid form of donepezil: Preparation, characterization and formulation development
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.112308
Abstract: Abstract The aim of this study was to transform donepezil into ionic liquids (ILs) to promote its skin permeability for developing a new delivery mode of donepezil. Donepezil ILs were formed by pairing with docusate,… read more here.
Keywords: donepezil; ionic liquid; liquid form; permeability ... See more keywords
Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14030
Abstract: Alzheimer's disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors donepezil, galantamine and rivastigmine and the N‐methyl‐D‐aspartate‐receptor antagonist memantine. Donepezil acts primarily… read more here.
Keywords: donepezil; beyond symptomatic; alzheimer disease; treatment ... See more keywords
Donepezil HCl Liposomes: Development, Characterization, Cytotoxicity, and Pharmacokinetic Study
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DOI: 10.1208/s12249-022-02209-9
Abstract: The current research work aims to study the pharmacokinetic and nasal ciliotoxicity of donepezil liposome–based in situ gel to treat Alzheimer’s disease. The physicochemical properties and first-pass metabolism of donepezil HCl result in low concentrations… read more here.
Keywords: situ gel; study; donepezil hcl; donepezil ... See more keywords
Cognitive Enhancer Donepezil Attenuates Heroin-Seeking Behavior Induced by Cues in Rats.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin2203076
Abstract: PURPOSE Opioid use disorder is a significant global problem. Chronic heroin use is associated with impairment of cognitive function and conscious control ability. The cholinergic system can be disrupted following heroin administration, indicating that activation… read more here.
Keywords: administration; heroin; induced cues; heroin seeking ... See more keywords
Development of a Rapid LC-MS/MS Method for Simultaneous Quantification of Donepezil and Tadalafil in Rat Plasma: Its Application in a Pharmacokinetic Interaction Study after Oral Administration in Rats
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052352
Abstract: This study aimed to establish a simple and sensitive analytical method to simultaneously quantify donepezil (DPZ) and tadalafil (TAD) in rat plasma using lansoprazole (LPZ) as an internal standard (IS) by using liquid chromatography tandem… read more here.
Keywords: quantification; administration; rat plasma; donepezil ... See more keywords
Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats
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DOI: 10.3390/pharmaceutics14010005
Abstract: Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel… read more here.
Keywords: donepezil loaded; drug; sustained release; donepezil ... See more keywords
Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil Transdermal Patches
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DOI: 10.3390/pharmaceutics14010205
Abstract: Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic… read more here.
Keywords: spectroscopy; donepezil; ionic liquid; dpz ... See more keywords