Donor T Cell Independent Mechanism May Contribute to Enhancing Steroid Refractory Gvhd in Murine Models
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.669
Abstract: Steroids are the first line therapy for acute GVHD but 50% of patients develop steroid refractory GVHD (SR-GVHD). The development of therapies for SR-GVHD is limited by incomplete understanding of its pathophysiology. Here we generated… read more here.
Keywords: steroid refractory; gvhd; donor cell; gvhd murine ... See more keywords
Transplant- and Disease-Related Outcomes of Allogeneic Hematopoietic Stem Cell Transplant in Patients with Cerebral Adrenoleukodystrophy Vary By Donor Cell Source, Conditioning Regimen, and Stage of Cerebral Disease
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.523
Abstract: Early treatment with allogeneic hematopoietic stem cell transplantation (allo-HSCT) for cerebral adrenoleukodystrophy (CALD) has a beneficial effect on clinical indices of disease and long-term survival but is associated with immunologic risks. We aim to understand… read more here.
Keywords: source; disease; transplant; donor cell ... See more keywords
Irradiation dependent inflammatory response may enhance satellite cell engraftment
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68098-9
Abstract: Skeletal muscle stem (satellite) cells transplanted into host mouse muscles contribute to muscle regeneration. Irradiation of host muscle enhances donor stem cell engraftment by promoting the proliferation of transplanted donor cells. We hypothesised that, similar… read more here.
Keywords: muscle; cell engraftment; donor cell; cell ... See more keywords
Minimally Invasive Muscle Embedding Generates Donor-Cell-Derived Muscle Fibers that Express Desmin and Dystrophin.
Sign Up to like & getrecommendations! Published in 2020 at "Military medicine"
DOI: 10.1093/milmed/usz203
Abstract: INTRODUCTION The aim of this study was to quantify the extent of donor-cell-derived myogenesis achieved by a novel surgical technique known as Minimally Invasive Muscle Embedding (MIME). MATERIALS AND METHODS Through MIME, we implanted a… read more here.
Keywords: muscle; cell derived; minimally invasive; muscle fibers ... See more keywords
Pediatric Donor Cell Acute Lymphoblastic Leukemia Following Bone Marrow Transplant for GATA2 Mutation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002437
Abstract: Donor cell leukemia is a rare complication following hematopoietic stem cell transplant (HSCT). There are currently few reports in children and only rare, reported cases of donor-derived myelodysplastic syndrome/acute myeloid leukemia in patients with an… read more here.
Keywords: cell; donor cell; leukemia; gata2 ... See more keywords
Exome sequencing reveals heterogeneous clonal dynamics in donor cell myeloid neoplasms after stem cell transplantation.
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2019.234609
Abstract: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for myeloid neoplasms (MN). In rare cases, the development of de novo hematologic malignancies derived from cells of donor origin, named donor cell hematologic… read more here.
Keywords: online supplementary; stem cell; transplantation; donor cell ... See more keywords