Early achievement of full donor chimerism after allogeneic hematopoietic stem cell transplantation predicts lower relapse risk in patients with acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2018.06.005
Abstract: Background: Acute lymphoblastic leukemia (ALL) remains one of the most difficult‐to‐cure hematological malignancies. Allogeneic hematopoietic stem cell transplantation (HSCT) provides curative potential but a substantial proportion of patients eventually will relapse. It is unknown if… read more here.
Keywords: chimerism; donor chimerism; relapse; acute lymphoblastic ... See more keywords
Systematic comparison of donor chimerism in peripheral blood and bone marrow after hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Blood Cancer Journal"
DOI: 10.1038/bcj.2017.42
Abstract: Incomplete donor chimerism (DC) after hematopoietic stem cell transplantation (HSCT) is associated with reduced overall and disease-free survival and decreasing DC can precede overt relapse of malignant diseases.1, 2 Sensitive chimerism quantification may therefore allow… read more here.
Keywords: chimerism; donor chimerism; cell transplantation; stem cell ... See more keywords
Preliminary high-dose irradiation of the recipient and associated damage of bone marrow stromal compartment enables bone marrow stroma transplantation
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DOI: 10.1038/s41598-025-07709-9
Abstract: Transplantability of allogeneic mesenchymal stem cells (MSCs) as a stable engraftment and participation in physiological renewal of bone marrow (BM) stroma remains an open question. We hypothesized that a necessary condition for successful MSCs transplantation… read more here.
Keywords: donor chimerism; recipient; stroma; bone marrow ... See more keywords
Successful bone marrow transplantation in 20 patients with severe congenital neutropenia using an immunosuppressive conditioning regimen: Results of a single institute
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DOI: 10.1182/blood-2025-1213
Abstract: Severe congenital neutropenia (SCN) is a rare heterogeneous genetic disorder characterized by recurrent bacterial infections from early infancy due to severe chronic neutropenia. The majority of patients with SCN have benefitted by treatment with granulocyte… read more here.
Keywords: donor chimerism; conditioning regimen; patients scn; bmt ... See more keywords
Complete donor chimerism following deceased-donor liver transplant in an adolescent with hepatitis-associated severe aplastic anemia
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DOI: 10.1182/blood-2025-3209
Abstract: Aplastic anemia (AA) develops in up to 28% percent of children with indeterminate acute liver failure (ALF), often within two months of liver disease onset. Immune destruction of hematopoietic stem cells (HSCs) is thought to… read more here.
Keywords: donor chimerism; gvhd; plt; liver ... See more keywords
Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1055497
Abstract: Introduction We previously reported the initial results of a phase II multicenter transplant trial using haploidentical parental donors for children and aolescents with high-risk sickle cell disease achieving excellent survival with exceptionally low rates of… read more here.
Keywords: immune reconstitution; cell; donor chimerism; disease ... See more keywords