Combined Hypothermic and Normothermic Machine Perfusion Improves Functional Recovery of Extended Criteria Donor Livers
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DOI: 10.1002/lt.25315
Abstract: Hypothermic oxygenated perfusion (HOPE) and normothermic perfusion are seen as distinct techniques of ex situ machine perfusion of the liver. We aimed to demonstrate the feasibility of combining both techniques and whether it would improve… read more here.
Keywords: recovery; perfusion; donor livers; machine perfusion ... See more keywords
Sequential Protocol Biopsies Post–Liver Transplant From Donors With Moderate Macrosteatosis: What Happens to the Fat?
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DOI: 10.1002/lt.25867
Abstract: The number of steatotic deceased donor livers encountered has continued to rise as a result of the obesity epidemic. Little is known about the histological characteristics of moderately macrosteatotic livers over time in the recipient… read more here.
Keywords: macrosteatosis; protocol biopsies; moderate macrosteatosis; donor livers ... See more keywords
Using organ perfusion to optimize donor livers
Sign Up to like & getrecommendations! Published in 2023 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000001054
Abstract: Purpose of review The shortage of donor organs has led to the use of marginal extended criteria donor (ECD) livers to increase access to liver transplant. Ex-vivo machine perfusion allows for treatment and assessment of… read more here.
Keywords: optimize donor; machine perfusion; perfusion; donor livers ... See more keywords
Protecting Donor Livers During Normothermic Machine Perfusion With Stem Cell Extracellular Vesicles.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000002124
Abstract: Two rapidly growing areas in transplantation research are the use of normothermic machine perfusion (NMP) of donor organs and the therapeutic use of stem cell-derived extracellular vesicles (EVs) to improve graft viability. In this issue… read more here.
Keywords: extracellular vesicles; perfusion; donor livers; normothermic machine ... See more keywords
Minimizing Risks of Liver Transplantation with Steatotic Donor Livers by Preferred Recipient Matching.
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DOI: 10.1097/tp.0000000000003052
Abstract: BACKGROUND Donor livers with ≥30% macrosteatosis (steatotic livers) represent a possible expansion to the donor pool, but are frequently discarded as they are associated with an increased risk of mortality and graft loss. We hypothesized… read more here.
Keywords: mortality; donor livers; donor; graft loss ... See more keywords
Metabolomics Differences of the Donor Livers Between In Situ and Ex Situ Conditions During Ischemia-free Liver Transplantation
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DOI: 10.1097/tp.0000000000004529
Abstract: Background. Ischemia-free liver transplantation (IFLT) has been innovated to avoid graft ischemia during organ procurement, preservation, and implantation. However, the metabolism activity of the donor livers between in the in situ and ex situ normothermic… read more here.
Keywords: metabolism; ischemia free; transplantation; livers situ ... See more keywords
Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion
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DOI: 10.1097/tp.0000000000004531
Abstract: Background. End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor livers prior to transplantation. The objective of this study was to provide support for bile composition as a marker of biliary viability and… read more here.
Keywords: situ normothermic; normothermic machine; donor livers; bile duct ... See more keywords
Critical Evaluation of Discarded Donor Livers in the Eurotransplant Region: Potential Implications for Machine Perfusion
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DOI: 10.12659/aot.938132
Abstract: Background There are still many offered donor livers that are declined during the allocation process. Machine perfusion offers the option to evaluate (especially marginal) donor organs and to better decide whether a graft has the… read more here.
Keywords: machine; machine perfusion; donor livers; critical evaluation ... See more keywords
A pilot study of ex-vivo MRI-PDFF of donor livers for assessment of steatosis and predicting early graft dysfunction
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DOI: 10.1371/journal.pone.0232006
Abstract: Background The utility of ex vivo Magnetic resonance imaging proton density fat fraction (MRI-PDFF) in donor liver fat quantification is unknown. Purpose To evaluate the diagnostic accuracy and utility in predicting early allograft dysfunction (EAD)… read more here.
Keywords: steatosis; donor livers; mri pdff; histology ... See more keywords
The Delivery of Multipotent Adult Progenitor Cells to Extended Criteria Human Donor Livers Using Normothermic Machine Perfusion
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01226
Abstract: Background: Pre-clinical research with multi-potent adult progenitor cells (MAPC® cells, Multistem, Athersys Inc., Cleveland, Ohio) suggests their potential as an anti-inflammatory and immunomodulatory therapy in organ transplantation. Normothermic machine perfusion of the liver (NMP-L) has… read more here.
Keywords: mapc cells; microscopy; human donor; perfusion ... See more keywords