Exploring predisposing factors and pathogenesis contributing to injuries of donor lungs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2022.2157264
Abstract: ABSTRACT Introduction Lung transplantation (LTx) remains the only therapeutic strategy for patients with incurable lung diseases. However, its use has been severely limited by the narrow donor pool and potential concerns of inferior quality of… read more here.
Keywords: donor lungs; exploring predisposing; predisposing factors; lung ... See more keywords
Prolonged Preservation of up to 24 Hours at 10 °C Does Not Impact Outcomes after Lung Transplantation
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DOI: 10.1097/sla.0000000000006632
Abstract: Objective: To determine the impact of prolonged storage of donor lungs at 10 °C for up to 24 hours on outcome after lung transplantation. Background: An increasing body of evidence suggests 10 °C as the… read more here.
Keywords: lung transplantation; impact; preservation; donor lungs ... See more keywords
Transplant suitability of rejected human donor lungs with prolonged cold ischemia time in low flow acellular and high flow cellular ex vivo lung perfusion systems.
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DOI: 10.1097/tp.0000000000002667
Abstract: BACKGROUND Ex vivo lung perfusion (EVLP) has the potential to increase the number of donor lungs available for lung transplantation (LTx). While the current maximum cold ischemia time (CIT) for donor lungs in clinical LTx… read more here.
Keywords: transplant suitability; flow; donor lungs; flow acellular ... See more keywords
Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abm7190
Abstract: Donor organ allocation is dependent on ABO matching, restricting the opportunity for some patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and FpGalactosaminidase, used in combination, have been described to effectively convert group… read more here.
Keywords: donor lungs; lung; group; blood type ... See more keywords
Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death
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DOI: 10.1186/s12931-017-0704-9
Abstract: BackgroundLung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflammatory and immunomodulatory role of human mesenchymal stromal… read more here.
Keywords: mscs evs; attenuate lung; ischemia; injury ... See more keywords
Donor Lungs’ Procurement Implementation with Ex Vivo Lung Perfusion in a Low-Volume Lung Transplant Center
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DOI: 10.3390/life15010037
Abstract: (1) Background: Ex Vivo Lung Perfusion (EVLP) is a technique designed to assess and recondition marginal lungs, potentially expanding the donor pool and improving transplant outcomes (2) Methods: This retrospective study evaluated lung transplantation outcomes… read more here.
Keywords: lung; perfusion; evlp; vivo lung ... See more keywords