Donor lymphocyte infusion for prevention of relapse after unmanipulated haploidentical PBSCT for very high-risk hematologic malignancies
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DOI: 10.1007/s00277-018-3482-7
Abstract: Unmanipulated haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) has been an established treatment to cure high-risk leukemia/lymphoma. Relapse is the main cause of treatment failure for patients with relapsed/refractory disease or with very high-risk gene… read more here.
Keywords: risk; high risk; pbsct; relapse ... See more keywords
Utilizing Data to Modify Standard Operating Procedures and Improve Outcomes: Evaluating Complications after Donor Lymphocyte Infusions in Allogeneic Stem Cell Transplant Recipients
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.412
Abstract: Introduction Despite major advances in hematopoietic cell transplant (HCT), 10-50% of patients relapse following allogeneic HCT. Donor lymphocyte infusion (DLI) is one treatment strategy for relapse that potentially provides a graft versus malignancy therapeutic effect.… read more here.
Keywords: cell transplant; donor lymphocyte; policy; cell ... See more keywords
[Donor Lymphocyte Infusions (DLI): Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin du cancer"
DOI: 10.1016/j.bulcan.2018.10.002
Abstract: Donor lymphocyte infusion (DLI) can be proposed to treat or prevent the relapse of malignant hemopathies following allogeneic stem cell transplantation. The efficiency has been mainly reported in the treatment of CML and low-grade lymphomas… read more here.
Keywords: infusions dli; donor lymphocyte; transplantation; lymphocyte infusions ... See more keywords
Decitabine in combination with donor lymphocyte infusions can induce remissions in relapsed myeloid malignancies with higher leukemic burden after allogeneic hematopoietic cell transplantation.
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DOI: 10.1016/j.leukres.2018.07.005
Abstract: The combination of 5-azacytidine (AZA) with donor lymphocyte infusions (DLIs) can induce remissions in patients with relapsed myeloid malignancies after allo-HCT. As decitabine (DAC) is known to be effective also in AML/MDS with leukocytosis, we… read more here.
Keywords: combination; allo hct; lymphocyte infusions; donor lymphocyte ... See more keywords
Donor-lymphocyte infusion following haploidentical hematopoietic cell transplantation with peripheral blood stem cell grafts and PTCy
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DOI: 10.1038/bmt.2017.193
Abstract: Donor-lymphocyte infusion (DLI) for relapse following haploidentical hematopoietic cell transplantation (haploHCT) with post-transplant cyclophosphamide (PTCy) has been described in recipients of bone marrow grafts, but not recipients of G-CSF mobilized peripheral blood (PB) grafts. We… read more here.
Keywords: dli; lymphocyte infusion; relapse; transplantation ... See more keywords
Combination Therapy With Chemotherapy, Donor Lymphocyte Infusion With Concurrent Blinatumomab in Relapsed/Refractory Acute Precursor B-Lymphoblastic Leukemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001789
Abstract: The therapeutic approach for relapsed/refractory acute lymphoblastic leukemia (ALL) remains to be a challenge. The patient was diagnosed as B-cell ALL at 6 months of age and relapsed for the second time following repeat allogeneic… read more here.
Keywords: blinatumomab; therapy; lymphocyte infusion; donor lymphocyte ... See more keywords
Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T‐cell subpopulations
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DOI: 10.1111/trf.14112
Abstract: Cryopreserved donor lymphocyte infusion (DLI) products are manufactured and administered to treat relapse after allogeneic hematopoietic stem cell transplantation. Reported clinical responses to DLIs vary broadly, even within the same group of patients. While there… read more here.
Keywords: cryopreservation donor; clinical methods; cryopreservation; methods cryopreservation ... See more keywords
Donor Lymphocyte Infusions After Allogeneic Stem Cell Transplantation in Acute Leukemia: A Survey From the Gruppo Italiano Trapianto Midollo Osseo (GITMO)
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DOI: 10.3389/fonc.2020.572918
Abstract: We conducted a retrospective multicenter study including pediatric and adult patients with acute leukemia (AL) who received donor lymphocyte infusions (DLIs) after allogeneic hematopoietic stem cell transplantation (HCT) between January 1, 2010 and December 31,… read more here.
Keywords: dli; lymphocyte infusions; stem cell; acute leukemia ... See more keywords
Comparison of Two Strategies for Prophylactic Donor Lymphocyte Infusion in Patients With Refractory/Relapsed Acute Leukemia
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DOI: 10.3389/fonc.2021.554503
Abstract: Prophylactic donor lymphocyte infusion (pDLI) could reduce relapse in patients with refractory/relapsed acute leukemia (RRAL) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT), but optimal timing of pDLI remains uncertain. We compared the outcomes of two… read more here.
Keywords: lymphocyte infusion; cohort; donor lymphocyte; day ... See more keywords