Inducing Donor MHC Chimerism with Bone Marrow Derived Exosomes in Non-Human Primates
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.430
Abstract: Purpose Our group has achieved cardiac allograft tolerance in non-human primates (NHPs) via hematopoietic cellular chimerism mediated through allogeneic bone marrow (BM) and kidney co-transplantation after non-myeloablative conditioning. This form of tolerance is believed to… read more here.
Keywords: bone marrow; donor mhc; mhc chimerism; chimerism ... See more keywords
March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05572-z
Abstract: In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving… read more here.
Keywords: alloimmunity; dcs; cd103; donor mhc ... See more keywords
Donor-derived exosomes: the trick behind the semidirect pathway of allorecognition
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Organ Transplantation"
DOI: 10.1097/mot.0000000000000372
Abstract: Purpose of review The passenger leukocyte hypothesis predicts that after transplantation, donor antigen-presenting cells (APCs) from the graft present donor MHC molecules to directly alloreactive T cells in lymphoid organs. However, in certain transplantation models,… read more here.
Keywords: semidirect pathway; mhc molecules; donor mhc; donor ... See more keywords