The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.
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DOI: 10.1016/j.atherosclerosis.2020.05.012
Abstract: BACKGROUND AND AIMS Peripheral arterial disease (PAD) is an important cause of morbidity and mortality with little effective medical treatment currently available. Nitric oxide (NO) is crucially involved in organ perfusion, tissue protection and angiogenesis.… read more here.
Keywords: angiogenesis arteriogenesis; mpc; mpc 1011; donor mpc ... See more keywords