Programmed Death Ligand-1-Overexpressing Donor Exosomes Mediate Donor-Specific Immunosuppression by Delivering Co-inhibitory Signals to Donor-Specific T Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300670
Abstract: Programmed death ligand-1 (PD-L1) and donor antigens are critical for donor immature dendritic cells (DCs) targeting donor-specific T cells to induce transplant tolerance. This study aimed to clarify whether DC-derived exosomes (DEX) with donor antigens… read more here.
Keywords: inhibitory signals; specific cells; donor specific; donor ... See more keywords
Method of Generating Tolerogenic Maturation-Resistant Dendritic Cells and Testing for Their Immune-Regulatory Functions In Vivo in the Context of Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8938-6_13
Abstract: During that past two decades, advances in techniques for generating in vitro immune-suppressive dendritic cells (DCs) have heralded the use of these pro-tolerogenic DCs as therapeutics against transplant rejection and autoimmune diseases. In transplantation, previous… read more here.
Keywords: dcs; donor; dendritic cells; maturation ... See more keywords
Changes in the Expression of Immune Proteasomes in the Liver after the Induction of Portal Tolerance Depending on Donor—Recipient Differences in Rats
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DOI: 10.1007/s10517-018-4049-2
Abstract: Induction of donor-specific tolerance in outbred Wistar rats (RT1u) and inbred August rats (RT1c) increased the expression of immune proteasome subunits in liver with a peak on day 7 after beginning of the induction. The… read more here.
Keywords: tolerance; immune proteasomes; expression immune; induction ... See more keywords
Development and validation of donor-specific STS markers for tracking alien introgressions into Brassica juncea (L.) Czern
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DOI: 10.1007/s11032-017-0714-9
Abstract: Alien introgressions into crop plants rely on phenotypic evaluation. Employing molecular markers could greatly accelerate this and help discover new alleles/QTLs. We report here a new strategy to develop markers for tracking introgression using genome… read more here.
Keywords: markers tracking; alien introgressions; specific sts; brassica juncea ... See more keywords
Characterization of follicular T helper cells and donor-specific T helper cells in renal transplant patients with de novo donor-specific HLA-antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical immunology"
DOI: 10.1016/j.clim.2021.108698
Abstract: T follicular helper (TFH) cells are a heterogeneous subset of immunocompetent T helper (TH) cells capable of augmenting B cell responses in lymphoid tissues. In transplantation, exposure to allogeneic tissue activates TFH cells increasing the… read more here.
Keywords: specific hla; helper; follicular helper; helper cells ... See more keywords
Benznidazole Therapy Post-Heart Transplant and Surveillance Trypanosoma cruzi Testing with Donor Specific Antibodies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1985
Abstract: Introduction Chagas disease (Trypanosoma cruzi infection), endemic throughout Latin America, has grown in geographic distribution due to changing migration patterns. While benznidazole (BZN) therapy (5 mg/kg/day x 60 days) is considered first-line treatment, data describing… read more here.
Keywords: therapy; post; heart; bzn therapy ... See more keywords
A Virtualcrossmatch-Based Strategy for Perioperative Desensitization in Lung Transplant Recipients with Pre-Formed Donor-Specific Antibodies: 3-year Outcome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.492
Abstract: Purpose Pre-formed donor-specific antibodies (pf-DSA) are associated with worse outcome after lung transplantation (LTx) and might limit access to LTx. A virtual crossmatch (CXM)-based strategy for perioperative desensitization protocol has been used for immunized LTx… read more here.
Keywords: ltx; pre formed; lung; formed donor ... See more keywords
P029 A successful case of stem cell transplant after desensitization of a strong donor-specific antibody
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.089
Abstract: A 71 year old female was initially diagnosed with myelodysplastic syndrome (del 5q) which progressed to AML one year later. Patient had pancytopenia, experienced bruising, and needed blood transfusions. Allogeneic stem cell transplant was recommended and… read more here.
Keywords: stem cell; specific antibody; cell transplant; donor specific ... See more keywords
P080 Case report, BANFF III rejection with IGM-donor specific antibody (DSA)
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.140
Abstract: Aim Testing for IgM anti-HLA antibodies is not routinely tested in the majority of the HLA laboratories, despite the harm that they might cause. We report here a case of 69 years old male with End… read more here.
Keywords: specific antibody; rejection; case; igm ... See more keywords
P240 Unmasking prozone, detecting the hidden donor specific antibody
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DOI: 10.1016/j.humimm.2017.06.300
Abstract: Aim Given evidence that donor specific antibodies (DSA) to Human Leukocyte Antigens (HLA) adversely affect kidney transplant outcome, sensitive techniques for detecting HLA antibodies have been developed. Single-antigen (SA) Luminex-based tests, in particular, are highly… read more here.
Keywords: p240 unmasking; antibody; donor; effect ... See more keywords
P126 Comparison study of CDC and flow crossmatch vs. donor specific antibodies in transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.183
Abstract: Aim Our approach to transplant highly sensitized patients has been to perform CDC crossmatch (XM) when the results of flow xm are above 200 mean channel shifts (MCS) with donor specific antibodies (DSA). The aim… read more here.
Keywords: mfi; study; cdc; specific antibodies ... See more keywords