Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia
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DOI: 10.1038/s41467-021-25223-0
Abstract: Acute leukemia relapsing after chemotherapy plus allogeneic hematopoietic stem cell transplantation can be treated with donor-derived T cells, but this is hampered by the need for donor/recipient MHC-matching and often results in graft-versus-host disease, prompting… read more here.
Keywords: donor unrestricted; cd1c; specific tcr; leukemia ... See more keywords
Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection
Sign Up to like & getrecommendations! Published in 2021 at "JCI Insight"
DOI: 10.1172/jci.insight.140074
Abstract: Progress in our understanding of MR1-restricted mucosa-associated invariant T (MAIT) cells has raised interest in harnessing these cells for immunotherapy. The innate-like response characteristics, abundance in the blood, donor-unrestricted nature, and tropism for tissues make… read more here.
Keywords: methodology; expansion; mait cells; mait ... See more keywords