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Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21820
Abstract: Leishmaniasis is a vector-borne disease caused by around 20 species of Leishmania. The main clinical forms of leishmaniasis are cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). VL is caused by Leishmania infantum in Central and…
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Keywords:
sterol methyltransferase;
leishmaniasis;
drug;
donovani ... See more keywords
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Published in 2021 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29922
Abstract: Leishmaniasis is a neglected tropical disease caused by the protozoan parasite Leishmania. It is endemic in more than 89 different countries worldwide. Sterol alpha‐14 demethylase (LdSDM), a sterol biosynthetic pathway enzyme in Leishmania donovani, plays…
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Keywords:
leishmaniasis;
sterol alpha;
drug;
donovani ... See more keywords
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Published in 2017 at "Acta tropica"
DOI: 10.1016/j.actatropica.2017.05.032
Abstract: In Turkey, the main causative agents are Leishmania tropica (L. tropica) and Leishmania infantum (L. infantum) for cutaneous leishmaniasis (CL) and L. infantum for visceral leishmaniasis (VL). In this study, we investigated leishmaniasis cases caused…
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Keywords:
infantum;
turkey;
leishmaniasis;
pcr ... See more keywords
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Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.03.023
Abstract: The present study evaluates in vitro the effect of two synthetic compounds of the 7-chloro-4-aryloxyquinoline series, QI (C17H12ClNO3) and QII (C18H15ClN4O2S), on Leishmania donovani parasites. The results obtained demonstrate that these compounds are able to…
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Keywords:
effect;
donovani;
membrane potential;
leishmania donovani ... See more keywords
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Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.12.012
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Visceral Leishmaniasis is a deadly parasitic disease caused by Leishmania donovani. Paucity exists in the discovery of novel chemotherapeutics against Leishmaniasis. In this study, we synthesized a natural…
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Keywords:
bgr carboline;
carboline quinazolinone;
donovani;
activity ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.022
Abstract: Molecular hybridization is a ligand based drug design approach is well known recent medicinal chemistry to design anti-parasitic agents. In the present study, we have designed a series of (1-phenyl-9H-pyrido [3,4-b]indol-3-yl) (4-phenylpiperazin-1-yl)methanone derivatives using molecular…
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Keywords:
design synthesis;
leishmanial activity;
anti leishmanial;
chemistry ... See more keywords
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Published in 2018 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2018.07.006
Abstract: The current study was designed to assess the anti-leishmanial effect of a semi-purified fraction of wild mushroom Grifola frondosa against Leishmania donovani, in vitro. A total of five extracts from three wild mushrooms [Grifola frondosa…
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Keywords:
purified fraction;
grifola frondosa;
semi purified;
donovani ... See more keywords
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Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.053
Abstract: Visceral leishmaniasis (VL) is one of the most devastating diseases of the tropical region caused by protozoan parasite Leishmania donovani. So far, there is no effective drug and vaccine available against this fatal disease. The…
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Keywords:
rna helicase;
rna;
dead box;
donovani ... See more keywords
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Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.001
Abstract: Ribokinase (RK) is an ATP dependent sugar kinase that enables the entry of ribose in the metabolism. Leishmania accumulates ribose into the cytosol through hydrolysis of nucleosides and by transport from the extracellular environment. Activation…
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Keywords:
unraveling structural;
structural insights;
insights ribokinase;
donovani ... See more keywords
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Published in 2019 at "Parasitology international"
DOI: 10.1016/j.parint.2019.102047
Abstract: Leishmania donovani, a protozoan parasite of family Trypanosomatidae, causes fatal visceral leishmaniasis (VL) in the Indian subcontinent and Africa and cutaneous leishmaniasis (CL) in Sri Lanka. Another member of Trypanosomatidae, Leptomonas seymouri, resembling Leishmania was…
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Keywords:
leishmaniasis;
diagnosis;
donovani;
leishmania donovani ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34812-x
Abstract: Leishmania donovani is responsible for visceral leishmaniasis, a neglected and lethal parasitic disease with limited treatment options and no vaccine. The study of L. donovani has been hindered by the lack of a high-quality reference…
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Keywords:
virulence;
reference genome;
leishmania donovani;
donovani ... See more keywords